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Cirrhosis

Cirrhosis

Cirrhosis is severe scarring of the liver. This serious condition can be caused by many forms of liver diseases and conditions, such as hepatitis or chronic alcoholism.

 

Each time your liver is injured — whether by excessive alcohol consumption or another cause, such as infection — it tries to repair itself. In the process, scar tissue forms. As cirrhosis gets worse, more and more scar tissue forms, making it difficult for the liver to do its job. Advanced cirrhosis is life-threatening.

The liver damage caused by cirrhosis generally can’t be undone. But if liver cirrhosis is diagnosed early and the underlying cause is treated, further damage can be limited. In rare cases, it may be reversed.

Cirrhosis often has no symptoms until liver damage is severe. When symptoms do occur, they may include:

  • Fatigue.
  • Easily bleeding or bruising.
  • Loss of appetite.
  • Nausea.
  • Swelling in the legs, feet or ankles, called edema.
  • Weight loss.
  • Itchy skin.
  • Yellow discoloration in the skin and eyes, called jaundice.
  • Fluid accumulation in the abdomen, called ascites
  • Spiderlike blood vessels on the skin.
  • Redness in the palms of the hands.
  • Clubbing of the fingers, in which the fingertips spread out and become rounder than usual.
  • Confusion, drowsiness or slurred speech.

A wide range of diseases and conditions can damage the liver and lead to cirrhosis.

 

Some of the causes include:

  • Long-term alcohol abuse.
  • Ongoing viral hepatitis (hepatitis B, C and D).
  • Nonalcoholic fatty liver disease, a condition in which fat accumulates in the liver.
  • Autoimmune hepatitis, which is a liver disease caused by the body's immune system.
  • Wilson's disease, a condition in which copper accumulates in the liver.
  • Inherited disorders of sugar metabolism, such as galactosemia or glycogen storage disease.
  • Medications, including methotrexate or isoniazid.
  • Many more causes

Risk factors

  • Drinking too much alcohol. Excessive alcohol consumption is a risk factor for cirrhosis.
  • Fatty liver: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
  • Having viral hepatitis. Not everyone with chronic hepatitis will develop cirrhosis, but it's one of the world's leading causes of liver disease.

Complications

Complications of cirrhosis can include:

  • High blood pressure in the veins that supply the liver. This condition is known as portal hypertension. Cirrhosis slows the regular flow of blood through the liver. This increases pressure in the vein that brings blood to the liver.
  • Swelling in the legs and abdomen.The increased pressure in the portal vein can cause fluid to accumulate in the legs, called edema, and in the abdomen, called ascites. Edema and ascites also may happen if the liver can't make enough of certain blood proteins, such as albumin.
  • Enlargement of the spleen. Portal hypertension can cause the spleen to trap white blood cells and platelets. This makes the spleen swell, a condition known as splenomegaly. Fewer white blood cells and platelets in your blood can be the first sign of cirrhosis.
  • Bleeding. Portal hypertension can cause blood to be redirected to smaller veins. Strained by the extra pressure, these smaller veins can burst, causing serious bleeding. Portal hypertension also may cause enlarged veins, called varices, in the esophagus or the stomach. These varices also may lead to life-threatening bleeding. If the liver can't make enough clotting factors, this also can contribute to continued bleeding.
  • Infections. If you have cirrhosis, your body may have a hard time fighting infections. Ascites can lead to bacterial peritonitis, a serious infection.
  • Malnutrition. Cirrhosis may make it more difficult for your body to process nutrients, leading to weakness and weight loss.
  • Buildup of toxins in the brain. A liver damaged by cirrhosis can't clear toxins from the blood as well as a healthy liver can. These toxins can then build up in the brain and cause mental confusion and difficulty concentrating. This is known as hepatic encephalopathy. With time, hepatic encephalopathy can progress to unresponsiveness or coma.
  • Jaundice. Jaundice occurs when the diseased liver doesn't remove enough bilirubin, a blood waste product, from your blood. Jaundice causes yellowing of the skin and whites of the eyes and darkening of urine.
  • Bone disease. Some people with cirrhosis lose bone strength and are at greater risk of fractures.
  • Increased risk of liver cancer. A large proportion of people who develop liver cancer have pre-existing cirrhosis.
  • Acute-on-chronic cirrhosis. Some people end up experiencing multiorgan failure. Researchers now believe this is a complication in some people who have cirrhosis. However, they don't fully understand what causes it.

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